Endocrine Abstracts

Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) is present in a high percentage of obese patients undergoing bariatric surgery (BS), being an effective strategy for the remission of MAFLD. A significant proportion of patients still have steatohepatitis even after considerable weight loss and metabolic improvements. Liver biopsy remains the definitive test to classify a patient with steatohepatitis, but it is an invasive test. The use of non-invasive ...

Introduction: Ghrelin is a gastrointestinal peptide involved in the regulation of body weight and energy balance. However, its behavior after bariatric surgery and its relationship with other biochemical variables is still under discussion. We aim to undertake a simultaneous evaluation of the changes in ghrelin levels after three types of bariatric surgery and its relationship with different variables.Design: The study included 21 non-obese and 103 morbi...

Introduction: Obesity is associated with an increasing risk of diabetes and atherosclerosis. Previous studies in animals show that oxidized low-density lipoprotein (Ox-LDL) can be captured by the adipocyte through different scavenger receptors (SR) and thus contribute to the worsening of insulin resistance (IR). We analyze the association between Ox-LDL levels and different SR present in adipose tissue and their relationship with the presence of obesity and insulin resistance ...

Introduction: HIF-1α, a hypoxia marker, is an important factor for transcriptional regulation of cell metabolism and the adaptation to cellular stress. It modulates the function of phagocytic cells by stimulating surface receptors such as scavenger receptors. But little is known on their relationship in adipose tissue, whose increase has been associated with an increased risk of atherosclerosis. The aim of this study is to analyze in adipose tissue the association between...

Introduction: The stearoyl-CoA desaturase 1 (SCD1) is an enzyme involved in the metabolism of fatty acids, and seems to be involved in the regulation of atherosclerosis development. In this study we want to check the expression of SCD1 in visceral and subcutaneous adipose tissue and its relationship with the metabolic syndrome.Methods: We measured SCD1 mRNA and protein expression in visceral and subcutaneous adipose tissue from 25 morbidly obese patients...

Introduction: Bariatric surgery (BS) is an effective strategy for the remission of non-alcoholic steatohepatitis (NASH) in morbidly obese (MO) patients, producing an improvement in comorbidities and better glycaemic control in patients with DM2. Liver biopsy remains the definitive test to classify a patient with NASH/NASH, however, the use of non-invasive techniques such as fibroscan would avoid the limitations and risks that biopsy can cause in this type of patient. Therefore...